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Stimulate collagen production with essential oils

Collagen is often referred to as the "protein of youth". Present in the skin, cartilage, ligaments, tendons, and even vascular walls, it plays a fundamental role in the structure and resilience of our tissues. However, from the age of 25-30, its natural production gradually declines, accelerating the visible signs of aging, as well as certain joint or circulatory weaknesses.

To this natural loss, several aggressions are added: UV rays, pollution, oxidative stress, chronic inflammation, and the action of degrading enzymes such as MMPs (matrix metalloproteinases).
In this context, it becomes relevant to consider a comprehensive approach: not only stimulating the production of new collagen, but also protecting the existing one, and creating an environment conducive to its stability. This is precisely what some medicinal plants and essential oils offer, rich in active compounds targeting these different levers.
Understanding Collagen: Structure, Role and Dynamics
Collagen is a fibrous protein that forms the framework of connective tissue.

There are at least 28 types of collagen identified to date, but types I, II, and III represent more than 90% of the total collagen in the body. These are also the ones most often targeted by dietary supplements and cosmetics:

  • Type I: the most abundant, structuring the skin, tendons, and bones.
  • Type II: specific to articular cartilage.
  • Type III: associated with the elasticity of flexible connective tissues (young skin, blood vessels, lungs).
The synthesis of collagen relies on the activity of specialized cells in the connective tissue: the fibroblasts. These cells produce and organize collagen fibers, in response to specific biological signals.
Among these signals, the TGF-β1 (Transforming Growth Factor Beta 1) plays a central role. It triggers a cellular signaling cascade called the Smad pathway, which activates the expression of genes involved in the production of collagen, particularly types I and III.

But this production can only occur efficiently if certain enzymatic cofactors are present. In particular, vitamin C is essential for the hydroxylation of proline and lysine, two amino acids necessary for the correct formation of the collagen triple helix. Without it, even if the fibroblasts are activated, the fibers produced will be unstable or degraded.

The degradation of collagen is mainly linked to:

  • the action of the enzymes MMP-1, MMP-2 and MMP-9,
  • to oxidative stress (free radicals),
  • to glycation, a phenomenon accelerated by a diet rich in fast sugars.

Three natural levers to act on collagen

1 - Stimulate the synthesis of new collagen

Numerous plant compounds promote collagen production through the activation of TGF-β1, fibroblast proliferation, or the supply of metabolic cofactors. Among them are:

  • Asiaticoside (Centella asiatica)
  • Ginsenosides (Panax ginseng)
  • Italidiones (Helichrysum italicum)
  • Linalool (Lavender, Ho Wood)
  • Vitamin C (Rosehip, Sea Buckthorn, Acerola)

2 - Protect Existing Collagen

This involves inhibiting the enzymes responsible for its degradation:
  • Geraniol (Rose Geranium, Palmarosa) inhibits MMP-1
  • Rutin and chlorogenic acid (Aronia melanocarpa, green tea)
  • Anethole (anise, dose-dependent)

3 - Reduce Inflammation and Oxidative Stress

Chronic inflammation indirectly activates degradation enzymes. The presence of antioxidants and anti-inflammatories in the tissue environment promotes collagen stability.

  • α-pinene (frankincense, cistus, pine)
  • Limonene (citrus)
  • β-caryophyllene (copaiba, black pepper)
  • Polyphenols (pomegranate, green tea, turmeric)

Overview of the most promising plants and essential oils

Plant / Essential Oil (EO) | Active Compounds | Mechanisms | Route of Use | Level of Evidence --- | --- | --- | --- | --- Centella asiatica | Asiaticoside, madecassoside | TGF-β↑, fibroblasts↑ | Oral / Topical | ++++ Panax ginseng | Ginsenoside Rg3 | TGF-β/Smad, ERK | Oral | +++ Coriander EO | Linalool | TGF-β↑, MMP-1↓ | Topical | +++ Rose Geranium EO | Geraniol | Inhibition of MMP-1 | Topical | ++ Italian Helichrysum EO | Italidiones | Intense regeneration | Topical | ++ Aloe vera | Polysaccharides | Antioxidant, fibroblasts↑ | Topical | +++ Green tea | EGCG | Antioxidant, MMP↓ | Oral / Topical | ++++ Rosehip (HV) | Natural Retinoids | Regeneration | Topical | +++
Homemade Recipe: Regenerating Pro-Collagen Serum
For a 30mL bottle
Aromatic Core
  • 5 drops of Cistus ladanifer essential oil
  • 5 drops of Rosemary verbenone essential oil
  • 5 drops of Clary Sage essential oil
  • 5 drops of Wild Carrot essential oil

Lipid Matrix

For the plant-based matrix, we offer 4 variants:

Synergy 1 - "Complete Action" (3 oils)
Jojoba 50%
Black Seed 30%
Apricot Kernel 20%
This synergy combines the direct action of black seed on collagen, the perfect penetration of jojoba, and the regenerating softness of apricot kernel. Fluid texture, discreet scent, maximum effectiveness: it's the perfect balance between performance and daily use comfort.

Synergy 2 - "Pure Softness" (2 oils)
Jojoba 70%
Apricot Kernel 30%
Ideal for sensitive skin or those who prefer a minimalist approach. This combination offers an exceptional silky texture and a very neutral scent, while providing vitamins A and E to support skin regeneration.

Synergy 3 - "Maximum Protection" (3 oils)
Jojoba 40%
Sesame 35%
Black Seed 25%
For those seeking enhanced antioxidant protection. Sesame provides its specific antioxidants (sesamolin, sesamin) which perfectly complement the action of black seed on collagen. Recommended for mature skin or skin exposed to environmental aggressions.

Synergy 4 - "Antioxidant Simplicity" (2 oils)
Jojoba 60%
Sesame 40%
The simplest but very effective synergy, focusing on the synergy between the regulation of jojoba and the antioxidant power of sesame. Perfect for a preventive anti-aging routine or as a complement to other active treatments.

Instructions for use: Apply 3-4 drops in the evening on clean, damp skin. Massage well in upward movements.

Precautions: Do not use in case of pregnancy and breastfeeding or in children. Prior skin test recommended.

To Conclude

Phytotherapy and aromatherapy offer valuable tools to promote collagen production, protect its structures, and preserve the youthfulness of tissues. Far from miracle promises, it is through regular, reasoned, and well-documented use that these approaches reveal their full effectiveness.

In light of current data, a synergy between plant extracts, essential oils, and overall lifestyle constitutes one of the most promising natural means to support connective tissue throughout life.

Scientific References
Addis, R., Cruciani, S., Santaniello, S., Bellu, E., Sarais, G., Ventura, C., Maioli, M., & Pintore, G. (2020). Fibroblast proliferation and migration in wound healing by phytochemicals: Evidence for a novel synergic outcome. International Journal of Medical Sciences, 17(8), 1030–1042. Andrulewicz-Botulińska, E., Kuźmicz, I., Nazaruk, J., Wosek, J., & Galicka, A. (2019). The concentration-dependent effect of anethole on collagen, MMP-2 and GAG in human skin fibroblast cultures. Advances in Medical Sciences, 64(1), 94–101. Bahramsoltani, R., Farzaei, M. H., & Rahimi, R. (2014). Medicinal plants and their natural components as future drugs for the treatment of burn wounds: An integrative review. Archives of Dermatological Research, 306(7), 601–617. Bondarenko, L., Kalachinskaya, M., Serhiichuk, N., Motronenko, V., & Biloshytska, O. (2023). Possibilities of plant preparations use for collagen structure and metabolism disturbances correction: Modern state of problem. Innovative Biosystems and Bioengineering, 7(1), 6–24. Chang, H. C., Lin, Y. K., Liang, C. H., Huang, H. W., Lin, Y. H., Lin, Y. H., Hu, W. C., & Chiang, C. F. (2021). Collagen formula with Chinese herbal medicine can improve skin condition and reduce inflammation: A double-blind, randomized, placebo-controlled trial. Nutrition & Food Science, 51(6), 1166–1179. Garg, C. (2017). Molecular mechanisms of skin photoaging and plant inhibitors. International Journal of Green Pharmacy, 11(2), 217–223. Kanlayavattanakul, M., & Lourith, N. (2015). An update on cutaneous aging treatment using herbs. Journal of Cosmetic and Laser Therapy, 17(5), 227–232. Nobile, V., Schiano, I., Germani, L., Cestone, E., Navarro, P., Jones, J., & Caturla, N. (2023). Skin anti-aging efficacy of a four-botanical blend dietary ingredient: A randomized, double-blind, clinical study. Cosmetics, 10(1), 16. Salem, M. A., Manaa, E. G., Osama, N., Aborehab, N. M., Ragab, M. F., Haggag, Y. A., Ibrahim, M., & Hamdan, D. I. (2022). Coriander (Coriandrum sativum L.) essential oil and oil-loaded nano-formulations as an anti-aging potentiality via TGFβ/SMAD pathway. Scientific Reports, 12, 6783. TCI Co., Ltd. (2020). Investigation of the efficacies of multi berries juice on antioxidant effect and improvement of skin conditions. Clinical trial registration: NCT04878523. Goia-Socol, M. (2018). Effects of Arom Digest Slim on metabolic profile and food behaviour in overweight persons. Clinical trial registration: NCT03533881.

The Products

Essential Oil of Cistus 100% Organic and Handmade

Essential Oil of Cistus 100% Organic and Handmade

The Essential Oil of Cistus from Essenciagua, derived from the artisanal distillation of the Cistus Ladaniferum plant, is an exceptional product with unique healing and regenerating properties. This oil, extracted in accordance with traditional distillation practices, retains all the therapeutic virtues of the plant, thus offering maximum quality and effectiveness.

Cistus is recognized for its powerful properties in terms of skin healing and regeneration. This essential oil is...

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Rosemary Verbenone Essential Oil 100% Organic and Handmade

Rosemary Verbenone Essential Oil 100% Organic and Handmade

The Verbenone Rosemary Essential Oil from Essenciagua, certified organic and artisanally distilled, is a concentrate of natural benefits. Originating from France, particularly from Corsica and southern regions, Verbenone Rosemary (Rosmarinus officinalis - Verbenum) is a robust perennial plant, fond of maritime climates, and known for its needle-shaped leaves and whitish to blue flowers.

This essential oil is particularly effective in treating liver problems and bile insufficiency,...

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Essential Oil of Clary Sage 100% Organic and Handmade

Essential Oil of Clary Sage 100% Organic and Handmade

The Essential Oil of Clary Sage is a natural treasure with multiple virtues. Derived from Salvia Sclarea, a hardy and perennial plant native to France, this oil is distinguished by its musky fragrance and pale blue flowers. Artisanally distilled, it is certified organic and retains all its purity and effectiveness.

This essential oil is recognized for its positive action on female hormonal balance. It is particularly beneficial during menopause, helping to alleviate hot flashes,...

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Wild Carrot Essential Oil 100% Organic and Handmade

Wild Carrot Essential Oil 100% Organic and Handmade

The Wild Carrot Essential Oil from Essenciagua, distilled from Daucus Carota and certified organic, is a treasure of nature for health and beauty. It is particularly effective in supporting the liver system, helping to regenerate liver cells and improve its functions. This property makes it indispensable in the fight against liver disorders and body detoxification.

Rich in carotenoids and vitamins, this essential oil is also a powerful ally for the skin. It helps to revitalize...

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Jojoba Vegetable Oil

Jojoba Vegetable Oil

Discover Essenciagua’s Jojoba Vegetable Oil, certified 100% organic by Certisys and bearing the “Biogarantie” label. This oil, derived from the seed of the jojoba, a shrub native to the desert regions of North America, is a marvel of nature for skin and hair care.

Its unique composition is similar to human sebum, which gives it deep and effective penetration without leaving a greasy film on the skin. It is suitable for all skin types, moisturizing dry skin while...

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Nigella Vegetable Oil

Nigella Vegetable Oil

The Essenciagua’s Vegetable Oil of Nigella, certified 100% organic by Certipaq Bio, is an exceptional product with multiple and versatile benefits. Known for its effectiveness and versatility, this natural treasure is suitable for everyone, offering a complete solution for various care needs.

This oil, extracted from the seeds of Nigella sativa, is rich in essential fatty acids, vitamins and minerals, making it an excellent choice for skin care. It is particularly...

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Apricot Kernel Vegetable Oil

Apricot Kernel Vegetable Oil

The Apricot Kernel Vegetable Oil from Essenciagua is a natural, pure, and organic essence, obtained through careful extraction from apricot kernels. This oil is highly appreciated for its numerous virtues, particularly in beauty care, especially for the face. Its light texture and quick absorption make it ideal for all skin types, including sensitive skin.

Rich in vitamins A and E, as well as essential fatty acids, Apricot Kernel Oil is an excellent natural moisturizer. It...

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Sesame Vegetable Oil

Sesame Vegetable Oil

The Vegetable Sesame Oil from Essenciagua is an organic product, certified by Certipaq Bio, rich in essential fatty acids and antioxidants. This superior quality oil, which does not leave a greasy film on the skin, is particularly suited for the creation of homemade cosmetics for the face.

Thanks to its richness in nutrients, this oil nourishes and hydrates the skin deeply. It is ideal for facial care, contributing to improve the elasticity and hydration of the skin. Its rapid...

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